منابع مشابه
Familial testicular germ cell tumor: no associated syndromic pattern identified
BACKGROUND Testicular germ cell tumor (TGCT) is the most common malignancy in young men. Familial clustering, epidemiologic evidence of increased risk with family or personal history, and the association of TGCT with genitourinary (GU) tract anomalies have suggested an underlying genetic predisposition. Linkage data have not identified a rare, highly-penetrant, single gene in familial TGCT (FTG...
متن کاملextragonadal germ cell tumor and male infertility
background: over recent decades a possible decrease in sperm quality and an increase in the incidence of testicular cancer have been reported in many populations. some recent findings, as cohort studies, showed an increased risk of testicular cancer in men with abnormal semen analysis. case: a 30 years old man referred to our clinic with chief compliant of infertility for 3 years. spermogram re...
متن کاملA hierarchical frailty model for familial testicular germ-cell tumors.
Using a 2-level hierarchical frailty model, we analyzed population-wide data on testicular germ-cell tumor (TGCT) status in 1,135,320 two-generational Norwegian families to examine the risk of TGCT in family members of patients. Follow-up extended from 1954 (cases) or 1960 (unaffected persons) to 2008. The first-level frailty variable was compound Poisson-distributed. The underlying Poisson par...
متن کاملIsochromosome 12p-positive pineal germ cell tumor.
We report the chromosomal characteristics of a recurrent pineal non-seminomatous germ cell tumor in a 16-year-old male patient. This non-seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter find...
متن کاملGiant Testicular Mixed Germ Cell Tumor
Objective: We report a case that we believe to be the largest example of a testicular mixed germ cell tumor with a clearly defined histology pattern. Clinical Presentation and Interventions: A 21-year-old patient consulted a urologist concerning a giant testicular mass. At the time of presentation the tumor measured 29 ! 20 ! 16 cm, with a weight of 4,850 g. Serum ·-fetoprotein was over 15,000 ...
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ژورنال
عنوان ژورنال: Indian Journal of Human Genetics
سال: 2012
ISSN: 0971-6866
DOI: 10.4103/0971-6866.96679